Ngenxa yokumuncwa komswakama okungokwemvelo kwekhabhoni emnyama, i-PE ehlanganisiwe emnyama iyazwela umswakama. Isikhathi eside sokugcina noma indawo yokugcina enzima izokwandisa okuqukethwe komswakama. Ngaphansi kwezimo ezijwayelekile kanye nokusetshenziswa, sincoma ukushisa kusengaphambili okungenani ihora eli-1 kanye nokushisa okuphezulu okungu-90 °C.